Anti-inflammatory effect of rain tree leaf extract gel (Samanea saman) on fibronectin expression: study experimental

Introduction: A traumatic ulcer is an open wound on the skin or mucous membranes that often results from trauma, such as scratches, bites, shocks, or pressure. Rain tree leaves (Samanea saman) have the potential to reduce pain and anti-inflammatory effects thanks to the flavonoid content. This extract works by inhibiting the cyclooxygenase and lipoxygenase pathways, which help limit inflammation and accelerate wound healing. This study aims to evaluate the effects of a 12% concentration rain tree leaf (Samanea saman) extract gel on fibronectin expression in the process of healing traumatic ulcers. Methods: This experimental laboratory study employed a post test only control group design. The sample consisted of male white rat wistar Rattus norvegicus and a gel of rain tree leaf extract extracted with a 98% ethanol solvent using a maceration method with a 12% concentration. Data analysis was performed using the Mann- Whitney U test. Results: The highest average was observed in the treatment group receiving the 12% rain tree leaf extract gel (Samanea saman), with an average value of 54.078, while the lowest average was found in the placebo gel control group, with a value of 22.462. Statistical analysis using the Mann-Whitney U test revealed a significant difference between groups (p = 0.004, p < 0.05). Conclusion: A 12% concentration of rain tree leaves (Samanea saman) extract gel significantly enhances fibronectin expression, contributing to the healing process of traumatic ulcers